Methylcobalamin, L-Methylfolate & Combination Tablet
About Composition
This is an oral combination of bioavailable B vitamins i.e L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate for improving epidermal nerve fiber density (ENFD) in the lower extremity of patients with diabetic peripheral neuropathy (DPN). Provides nutritional requirements needed to restore metabolic processes associated with diabetic neuropathy to maintain blood flow by increasing nitric oxide resulting in vasodilation.
Product Details
This is an oral combination of bioavailable B vitamins i.e L-methylfolate, methylcobalamin, and pyridoxal 5'-phosphate for improving epidermal nerve fiber density (ENFD) in the lower extremity of patients with diabetic peripheral neuropathy (DPN). Provides nutritional requirements needed to restore metabolic processes associated with diabetic neuropathy to maintain blood flow by increasing nitric oxide resulting in vasodilation.
L-methylfolate Primary biologically active isomer of folic acid and the primary form of folate in circulation; folic acid is a precursor of tetrahydrofolic acid, which is involved as a cofactor for transformylation reactions.
Pyridoxal 5′-phosphate (PLP) Active form of vitamin B6.
Methylcobalamin One of 2 forms of biologically active vitamin B12.
Indications and Usage
These tablets are indicated for the distinct nutritional requirements of patients with endothelial dysfunction who present with loss of protective sensation and neuropathic pain associated with diabetic peripheral neuropathy.
Mechanism of Action
Drug Interaction
Methylcobalamin: This includes prescription and over-the-counter (OTC) medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals drugs. Some medications that have serious interactions with Vitamin B12 are: Chlorambucil, Omeprazole, colchicines.
Pyridoxal-5-Phosphate: Drugs including Aspirin, anticoagulants ("blood thinners") such as Warfarin or heparin, anti-platelet drugs such as clopidogrel, and non-steroidal anti-inflammatory drugs such as ibuprofen or naproxen. It may affect blood sugar levelsalo.
Vitamin D3 interacts with alumunium containing antacids and digoxin. L-methyl folate calcium interacts with warfarin and anticonvulsants.
Warning and Precautions
Consult your Doctor or Pharmacist, before taking this combination if:
● you are allergic to any of its ingredient
● if you are pregnant, planning to become pregnant, or are breast-feeding
● patients with a history of bipolar illness.
Side Effects
● Allergic reactions
● Acne
● Nausea
● Vomiting
● Abdominal pain
● Loss of appetite
● Somnolence
● Headaches
● Mild transient diarrhea
● Itching
● Edema